Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214956 | Tetrahedron | 2015 | 6 Pages |
Abstract
An efficient, short and convenient asymmetric synthesis of (R)-(+)-lipoic acid in seven steps from chiral hydroxy aldehyde with 32.5% overall yield is described. Synthesis of S and R enantiomers of α-lipoic acid from cis-1,4-butene diol derived chiral lactone is reported with 34 % overall yield. The present synthesis involves use of simple reaction conditions making it a convenient synthesis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Subhash P. Chavan, Kailash P. Pawar, Ch. Praveen, Niteen B. Patil,