Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214976 | Tetrahedron | 2015 | 10 Pages |
Abstract
A new synthetic protocol for the preparation of 3-aryl-3-methoxycarbonyl cyclopropenes with an unsubstituted double bond has been developed that allowed for expanded substrate scope and improved product yields. The method involves Rh(II)-catalyzed transfer of carbenoids generated from unpurified aryldiazoesters, followed by desilylation, and is compatible with a wide range of aryldiazoesters. The employed continuous extraction of hardly soluble crude diazoesters helps avoid laborious and often cost-prohibitive isolation and purification of sensitive diazoester precursors.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew Edwards, Michael Rubin,