| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5214999 | Tetrahedron | 2015 | 6 Pages |
Abstract
Operationally and user-simple a highly efficient one-pot three-component (5 molecules) coupling of α-enolic dithioesters, cysteamine hydrochloride and aldehydes afforded a range of thiazolopyridines in high yields under metal-free and solvent-free conditions. The new domino protocol generated two rings by the concomitant formation of seven multiple bonds (two C–C, three C–N and two C–S) involving a sequence of N,S-acetal formation/double Michael addition/N-cyclization as key steps in a single operation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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