Synthesis of surface-modified PAMAMs and PPIs for encapsulation purposes: influence of the decoration on their sizes and toxicity

First (PAMAM-G1) to fourth (PAMAM-G4) generation of PAMAM have been functionalized by the glycerol carbonate to yield a new family of dendrimers, the glycerodendrimers (GD-PAMAM-1 to GD-PAMAM-4). The cytotoxicity of these new dendrimers was tested on human MRC5 fibroblasts using the WST1 assay. These results concerning this family have been compared to the results obtained with the PPI family. The use of these GD-PPIs and GD-PAMAMs as encapsulating agents of organic compounds considered as pollutants was here demonstrated as well as their capacity to be regenerated.

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