Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5215063 | Tetrahedron | 2015 | 5 Pages |
Abstract
A series of novel chiral 3,4,5,6-tetrahydropyrimidinium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from (1S, 3S)-1,3-diphenyl-1,3-propanediamine. In situ prepared corresponding carbenes were tested in asymmetric copper-catalysed 1,4 conjugate addition of Grignard reagents to 3-methylcyclohexenone, allowing enantiomeric excesses of up to 87% to be achieved.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jie Li, Liang Xu,