Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5215108 | Tetrahedron | 2015 | 6 Pages |
Abstract
A mild and simple protocol is described for the palladium-catalyzed ligand-free Suzuki-Miyaura reaction of potassium aryltrifluoroborates in aqueous ethanol at room temperature. Palladium nanoparticles are generated in situ in the reaction and demonstrate high activity towards a wide range of aryl bromides and potassium aryltrifluoroborates, providing biphenyls in good to excellent yields. Interestingly, only 1Â equiv of K2CO3 is used in this catalytic system. Moreover, the key biaryl intermediate of 2-cyano-4â²-methylbiphenyl within valsartan is prepared in a 95% yield after 2Â h.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chun Liu, Xinmin Li, Zhanming Gao, Xinnan Wang, Zilin Jin,