Total synthesis of (−)-rhazinilam using 1,3-dipolar cycloaddition of optically active münchnone intermediate

A concise stereocontrolled total synthesis of (−)-rhazinilam was achieved by the regioselective 1,3-dipolar cycloaddition of a fully elaborated optically active münchnone intermediate prepared from d-aspartic acid dimethyl ester. The regiochemistry of the 1,3-dipolar cycloaddition of münchnone intermediate to various arylacetylenes was also investigated.

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