Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5215151 | Tetrahedron | 2015 | 6 Pages |
Abstract
Synthetic endeavors toward (â)-chaetominine via copper-catalyzed radical cyclization are reported. Both of the pyrido[2,3,b]-indole ring (C ring) and imidazolidinone (D ring) are efficiently constructed in one-pot manner. It's unveiled that the newly formed stereo center is controlled by the chiral of alanine, not by tryptophan. With these synthetic discoveries, highly efficient and diastereoselective synthesis of (+)-2,3,14-epi-chaetominine 5 and (â)-11-epi-chaetominine 11 is achieved.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xu Deng, Kangjiang Liang, Xiaogang Tong, Ming Ding, Dashan Li, Chengfeng Xia,