Article ID Journal Published Year Pages File Type
5215238 Tetrahedron 2015 6 Pages PDF
Abstract

Hereby we report new reaction conditions to convert benzoic acids and more general (hetero)aromatic carboxylic acids into the corresponding n-heptyl esters by applying Novozym-435 as the biocatalyst in cyclohexane as the solvent. Very good yields are obtained in the esterification of a plethora of substituted acids with mild and straightforward reaction conditions. Direct esterification of the acid is favoured compared to transesterification of methyl benzoate under our reaction conditions in all cases studied. Recycling of the immobilised enzyme is feasible although with some minor limitations.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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