Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5215238 | Tetrahedron | 2015 | 6 Pages |
Abstract
Hereby we report new reaction conditions to convert benzoic acids and more general (hetero)aromatic carboxylic acids into the corresponding n-heptyl esters by applying Novozym-435 as the biocatalyst in cyclohexane as the solvent. Very good yields are obtained in the esterification of a plethora of substituted acids with mild and straightforward reaction conditions. Direct esterification of the acid is favoured compared to transesterification of methyl benzoate under our reaction conditions in all cases studied. Recycling of the immobilised enzyme is feasible although with some minor limitations.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daniela Giunta, Barbara Sechi, Maurizio Solinas,