Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases

The formation of a library of chalcogen-containing DNA nucleobase derivatives is presented. Reacting easily accessible 9-(2-bromoethyl)adenine with chalcogen-containing nucleophilic reagents led to a series of novel heteroatom derivatives incorporating S, Se and Te atoms in satisfactory yields. Two representative X-ray structures are reported.

Graphical abstractA number of novel DNA nucleobase derivatives containing chalcogens (S, Se and Te) have been synthesized in satisfactory yields.Figure optionsDownload full-size imageDownload as PowerPoint slide