| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5215387 | Tetrahedron | 2015 | 13 Pages |
Abstract
TiCl4-mediated aldol reactions of chiral methyl α-silyloxy ketones with a variety of aldehydes provide the corresponding 1,4-syn aldol adducts with moderate to high stereocontrol. This transformation represents a new approach to substrate-controlled acetate aldol reactions and complements the 1,4-anti asymmetric induction produced by the related α-benzyloxy ketones. This new approach could be useful in the design of more efficient syntheses of natural products.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adriana Lorente, Miquel Pellicena, Pedro Romea, Fèlix UrpÃ,