| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5215450 | Tetrahedron | 2014 | 5 Pages |
Abstract
Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Makoto Furutachi, Naoya Kumagai, Takumi Watanabe, Masakatsu Shibasaki,