| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5215561 | Tetrahedron | 2014 | 17 Pages |
Abstract
A number of isothiazolo[4,5-b]carbazole derivatives were prepared via a Diels–Alder approach involving thermally induced indole-2,3-quinodimethane intermediates. Preliminary biological tests revealed a GSK-3β kinase inhibitor (29) and some free NH group containing compounds (17d, 19c, 29) displayed selective human carbonic anhydrase I inhibitory activities.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis of new biologically active isothiazolo[4,5-b]carbazole-type tetracyclic derivatives via an indole-2,3-quinodimethane approach](/preview/png/5215561.png "First Page Preview: Synthesis of new biologically active isothiazolo[4,5-b]carbazole-type tetracyclic derivatives via an indole-2,3-quinodimethane approach")