Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5215577 | Tetrahedron | 2014 | 6 Pages |
Abstract
A set of variously substituted indazoles and hetero-aromatic derivatives were synthesized from o-halo-(het)arylaldehydes using a palladium catalyzed amination followed by cyclization. Starting from phenones, this process was extended to give 3-substituted indazoles. Moreover, N-1-substituted-indazoles can be reached by this strategy using an optional selective N-1-alkylation step during the process. This methodology offers a general and easy route for the synthesis of regioselectively substituted indazoles.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Emmanuelle Dubost, Silvia Stiebing, Thibault Ferrary, Thomas Cailly, Frédéric Fabis, Valérie Collot,