Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5215630 | Tetrahedron | 2015 | 8 Pages |
Abstract
A novel, general, and efficient one-pot sequential reaction toward a variety of 4-aminated-6-arylpyrrolo[2,3-d]pyrimidines from 5-alkynylpyrimidines has been developed. Microwave-assisted metal-free intramolecular cyclization and amination provided moderate to excellent yields of 4-aminated pyrrolo[2,3-d]pyrimidines in short reaction times. This method avoids the use of metal-catalyst and expensive additives and was shown to tolerate amines and anilines.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vanessa Prieur, Nina Heindler, Jaime Rubio-MartÃnez, Gérald Guillaumet, M. Dolors Pujol,