Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5215660 | Tetrahedron | 2014 | 6 Pages |
Abstract
A method for the synthesis of tri-substituted furans has been developed based on Cu(I)-catalyzed reaction of terminal alkynes with β-keto α-diazoesters. This method for the synthesis of 2,3,5-trisubstituted furans is operationally simple and applicable to wide substrate scope. Moreover, this synthesis employs cheap Cu(MeCN)4PF6 as the catalyst and no additional ligand is needed. Similar reaction has also been applied to ethyl (E)-2-diazo-3-(methoxyimino)butanoate for the synthesis of 2,3,5-trisubstituted N-methoxypyrroles with limited success.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mohammad Lokman Hossain, Fei Ye, Yan Zhang, Jianbo Wang,