| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5215672 | Tetrahedron | 2014 | 6 Pages |
Abstract
A highly enantioselective addition of diphenyl phosphite to ketimines derived from isatins has been developed employing bifunctional thiourea-tertiary amine organocatalysts. A variety of isatins derived ketimines react well with diphenyl phosphite in the presence of Cinchona-derived thiourea (epiCDT) to provide biologically important chiral 3-substituted 3-amino-2-oxindoles (3a-l) in good yield (up to 88%) and good enantioselectivity (up to 97% ee). The three-component version of the reaction through a domino aza-Wittig/phospha-Mannich sequence has successfully been explored.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Akshay Kumar, Vivek Sharma, Jasneet Kaur, Vikas Kumar, Suhel Mahajan, Naveen Kumar, Swapandeep Singh Chimni,