Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5215875 | Tetrahedron | 2014 | 12 Pages |
Abstract
A series of novel nucleoside analogues having dual bases (pyrimidine and triazole) and sugars have been synthesized by CuAAC reaction of azido sugars with propynylated pyrimidines. These compounds were evaluated for their in vitro α-glucosidase inhibitory activity. In this series, compounds 4b, 4d, 8a, 8b, 8c, 8e, 8g, 8h, and 8i exhibited very good inhibition of α-glucosidase enzyme. Nucleoside analogues 8a, 4b, 8h, and 8c displayed 47.4%, 41.8%, 39.4%, and 34.6% inhibition, respectively, comparable to the standard drug acarbose (53.4%).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ravi Kumar Thakur, Akansha Mishra, K.K.G. Ramakrishna, Rohit Mahar, Sanjeev K. Shukla, A.K. Srivastava, Rama P. Tripathi,