| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5215955 | Tetrahedron | 2014 | 7 Pages |
Abstract
A convenient and user-friendly method to yield benzamides from primary and secondary amines and various benzylic alcohols in the presence of a cheap iron salt (FeCl2·4H2O) and tert-butylhydroperoxide (70% in water) as a stoichiometric oxidant is described. Control experiments indicated that this reaction might involve radical species. This method proved to be general, generating a family of 30 benzamides and was applied to the preparative synthesis of anti-anxiety drug moclobemide.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xavier Bantreil, Nasreddine Kanfar, Nicolas Gehin, Ethan Golliard, Pauline Ohlmann, Jean Martinez, Frédéric Lamaty,