| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5216040 | Tetrahedron | 2014 | 11 Pages |
Abstract
The asymmetric synthesis of 1,3 and 1,4-disubstituted aromatic lipoxin A4 analogues has been accomplished. A total of eight analogues were synthesised in a convergent approach utilising Sharpless asymmetric epoxidation, asymmetric reduction and intermolecular Heck reactions. The set of analogues were assessed for their effect on the production of cytokines IL-12p40, IL-23, IL-6, IL-1β and TNFα. A positive inhibitory result was observed for the production of IL-6 and IL-1β.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gavin G. Haberlin, Ciara McCarthy, Robert Doran, Christine E. Loscher, Patrick J. Guiry,