Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216063 | Tetrahedron | 2014 | 7 Pages |
Abstract
A family of enantiopure azetidine-2-caboxamides was asymmetrically synthesized, and was examined as organocatalyst in direct aldol reactions. A well chosen chiral azetidine-2-caboxamide was found to smoothly catalyze the direct aldol reaction of various benzaldehydes with acetone in brine, and β-hydroxy ketones were produced with enantiomeric excess up to 96%. The reaction of benzaldehydes with cyclic ketones also led to the formation of anti-products in diastereomeric ratio up to 99:1 and enantiomeric excess up to 99%.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xixi Song, Ai-Xiang Liu, Shan-Shan Liu, Wen-Chao Gao, Min-Can Wang, Junbiao Chang,