Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216070 | Tetrahedron | 2014 | 8 Pages |
Abstract
A practical synthesis of α-haloaryl esters has been achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatsky reagents in the presence of catalytic Pd(dba)2 and Xantphos. This chemistry tolerates a variety of aryl halides and was successfully applied to the synthesis of Ibuprofen. The α-haloaryl ester products, exemplified by ethyl 2-(4-bromo-2-chlorophenyl)acetate (3a), can be further functionalized via palladium or copper catalysis to afford an array of α-aryl esters.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Brian Wong, Xin Linghu, James J. Crawford, Joy Drobnick, Wendy Lee, Haiming Zhang,