Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216096 | Tetrahedron | 2014 | 8 Pages |
Abstract
Palladium-catalyzed reaction of unsymmetrical allylic electrophiles with polyamines gives rise to regioisomeric allylic polyamines. An original catalytic procedure providing an efficient method for the regioselective synthesis of new classes of polyamino derivatives of biological interest is reported. Based on experimental considerations, a mechanistic rationale involving a thermodynamically controlled isomerization of the initially formed branched product is proposed to account for the total regioselectivity observed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cyril Pieri, Sébastien Combes, Jean Michel Brunel,