Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216218 | Tetrahedron | 2014 | 7 Pages |
Abstract
Four nucleoside diphosphate 6-deoxy-l-sugars have been efficiently synthesized by coupling sugar-1-phosphates prepared from the H-phosphonate precursors with nucleoside 5â²-phosphoropiperidates in the presence of 4,5-dicyanoimidazole (DCI) as the activator. Compared to the conventional 1H-tetrazole-promoted phosphoromorpholidate method, the new phosphoropiperidate/DCI system significantly shortened the reaction time and afforded nucleoside diphosphate sugars in excellent isolated yields.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qi Sun, Xingjian Li, Jian Sun, Shanshan Gong, Gang Liu, Guodong Liu,