Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216219 | Tetrahedron | 2014 | 11 Pages |
Abstract
We describe here the synthesis of a series of new molecules containing phenol and heteroaromatic moieties, compounds, which have been evaluated for their ability to inhibit Bax/Bcl-xL interactions in BRET assays. Among them, a triazole derivative 13, exhibit a very promising activity, being more potent than the reference compounds acylpyrogallol 1 and ABT 737. These preliminary results demonstrate that derivatives of this family can be attractive to develop new molecules with potent anticancer activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Duc Duy Vo, Fabien Gautier, Sophie Barillé-Nion, Philippe Juin, Nicolas Levoin, René Grée,