Aminosugar motifs via an allene aziridination strategy

Aminosugar motifs occur in many biologically active natural products and pharmaceuticals; however, stereocontrolled access to diverse structures with minimal use of protecting groups and oxidation state changes is challenging. This paper describes a chemo-, regio-, and stereoselective approach to aminosugar motifs that utilizes an allene aziridination strategy to rapidly install three of the contiguous heteroatom-bearing carbons with stereochemical flexibility.

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