| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5216394 | Tetrahedron | 2014 | 8 Pages |
Abstract
An organocatalytic enantioselective synthesis of α-methylene-γ-lactams has been developed. The reaction between protected 2-aminomalonates and Morita-Baylis-Hillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in excellent yields and moderate to good enantioselectivities, after work-up.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xavier Companyó, Pierre-Yves Geant, Andrea Mazzanti, Albert Moyano, Ramon Rios,