| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5216493 | Tetrahedron | 2013 | 9 Pages |
Abstract
New firefly luciferin analogs of the 4,4â²-substituted biphenyl-type were synthesized. One analog with a 4â²-dimethylamino group possessed bioluminescence activity, emitting near-infrared biological window light at 675Â nm suitable for deep-site bioimaging of living animals. The chemiluminescence light-emission maximum of the corresponding methyl ester of the bioluminescence active analog was 500Â nm, implying that biphenyl and thiazolinone rings in the light emitter might be placed in a coplanar conformation at the polar luciferase active site.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Chihiro Miura, Masahiro Kiyama, Satoshi Iwano, Kazuto Ito, Rika Obata, Takashi Hirano, Shojiro Maki, Haruki Niwa,