A one-pot synthesis of bisarylhydrazones by Cu(I)-catalyzed aerobic oxidation

An efficient Cu(I)-catalyzed one-pot synthesis of N-substituted (or NH) bisarylhydrazones is reported. A further cyclization reaction could occur towards the synthesis of benzimidazoles or triazoles with elevated temperature. A plausible alkylation–oxidation–alkylation mechanism is proposed based on experimental results and literature.

Graphical abstractAn efficient one-pot sequential synthesis of N-substituted (or NH) bisarylhydrazones based on Cu(I)-catalyzed aerobic oxidative coupling reaction has been developed. A further cyclization reaction could occur towards the synthesis of benzimidazoles or triazoles with elevated temperature. A plausible alkylation–oxidation–alkylation mechanism is proposed based on the control experiments.Figure optionsDownload full-size imageDownload as PowerPoint slide