| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5216558 | Tetrahedron | 2014 | 6 Pages |
Abstract
β-Lactam scaffold was fabricated regioselectively by a facile one-pot base-mediated synthesis. The reactions of bromoacetic acid 1, primary amines 2, isocyanides 3, and arylglyoxals 4 produced 2-aroyl-4-oxoazetidine-2-carboxamides 6 in good yields via a one-pot tandem Ugi condensation and intramolecular C-alkylation at room temperature in the presence of Cs2CO3.
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