| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5216566 | Tetrahedron | 2014 | 7 Pages |
Abstract
Catalytic activities of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA)-based mono- and dipeptides and their l-proline analogs in asymmetric aldol reaction were investigated. THIQA-based dipeptides showed better enantioselectivity than proline analogs, whereas proline-based dipeptides gave higher yield in the aldol reaction of cyclohexanone with several aldehydes in dichloromethane at â10 °C in the presence of benzoic acid.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cigdem Yolacan, Murat Emrah Mavis, Feray Aydogan,