Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216594 | Tetrahedron | 2014 | 5 Pages |
Abstract
Several acidic azolium salts prepared from oxazole, thiazole, and imidazole derivatives were investigated as catalysts in N-glycosylation reaction using a silylated modified pyrimidine and an acylated ribose or glucose to afford the corresponding pyrimidine nucleoside. Among the salts, 2-methyl-5-phenylbenzoxazolium perchlorate showed the highest catalytic activity. This salt is a nonhygroscopic crystalline compound that shows higher activity than the frequently used trimethylsilyl triflate. Reactions with this salt can be conducted in gram scales.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroshi Shirouzu, Hiroki Morita, Masaki Tsukamoto,