Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216608 | Tetrahedron | 2013 | 11 Pages |
Abstract
Lithium perchlorate and acetic anhydride were the key additives for the multi-component reaction between 3-aminocyclohex-2-enones, formaldehyde, and malonates yielding adducts that were annulated under acidic conditions to afford bicyclic 2,5-dioxooctahydroquinoline-3-carboxylates. When methyl cyanoacetate was subjected to the same reaction conditions in the presence of a catalytic amount of triphenylphosphine, the bicyclic 2,5-dioxooctahydroquinoline-3-carbonitriles were obtained in a one-flask reaction.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xingxian Gu, Gunda I. Georg,