Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216623 | Tetrahedron | 2013 | 8 Pages |
Abstract
The indoloquinoline alkaloids cryptolepine (1), neocryptolepine (2), isocryptolepine (3), and isoneocryptolepine (4) are important tools in traditional medicine. Now, their precursors 1a-4a were synthesized in two steps starting from the corresponding bromo-iodoquinolines. Our strategy is based on palladium-catalyzed reactions, applying regioselective Buchwald-Hartwig amination on 2,3- and 3,4-dihaloquinolines followed by an intramolecular Heck-type reaction. Both steps were carried out under microwave irradiation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Borbála Bogányi, Judit Kámán,