Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216630 | Tetrahedron | 2014 | 8 Pages |
Abstract
A stereocontrolled approach to functionalized acyclic β2,3-amino acid derivatives was accomplished from cis- or trans-2-aminocyclohexenecarboxylates derived from bicyclic β-lactam regioisomers. The transformations were based on oxidative ring cleavage through the ring C-C double bond of the cyclohexene β-amino esters, followed by functionalization of the dialdehyde intermediates with different phosphoranes. This stereospecific and stereocontrolled procedure was applied to the synthesis of acylic β2,3-amino acid derivatives functionalized with ester, nitrile, keto, alkyl or arylalkyl groups.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maria Cherepanova, Loránd Kiss, Ferenc Fülöp,