Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216718 | Tetrahedron | 2014 | 7 Pages |
Abstract
A new approach to the synthesis of medium-ring-sized trans-alkenolides, based on the oxidative fragmentation of a three-carbon ring in hydroxyalkyl substituted bicyclo[n.1.0]alkan-1-ols readily available from 2-alkylidenecycloalkanones, is described. This methodology was applied to the six-step transformation of cyclooctanone to the natural 12-membered trans-alkenolide antibiotic (+)-recifeiolide.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dzmitry M. Zubrytski, Dzmitry G. Kananovich, Oleg G. Kulinkovich,