| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5216719 | Tetrahedron | 2014 | 5 Pages |
Abstract
The NY-ESO-1 (A39-A68) peptide hydrazide was prepared through 9-fluorenyl-methoxycarbonyl solid-phase peptide synthesis (Fmoc SPPS) from a new 9-fluorenyl-methoxycarbonyl hydrazine 2-chlorotrityl chloride (Fmoc-hydrazine 2CTC) resin. The new resin was ideal for long-term storage and usage in Fmoc SPPS. Besides, the title peptide hydrazide could be transformed nearly quantitatively into the corresponding peptide thioester, which was both isolable and usable directly in native chemical ligation (NCL).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yi-Chao Huang, Chen-Chen Chen, Si-Jian Li, Shuai Gao, Jing Shi, Yi-Ming Li,