Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216732 | Tetrahedron | 2014 | 12 Pages |
Abstract
Transformation of plant-origin 7,14-dihydroxy-ent-kaurenes to ent-abietanes having a cis-fused α-methylene γ-lactones was accomplished efficiently under the Mitsunobu reaction conditions. The yields of the desired products were apparently influenced by the steric hindrance at C-1. The cytotoxic activity on P388 murine leukemia cells of the ent-abietanes having cis-fused α-methylene γ-lactones produced were assayed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yutaka Aoyagi, Kei Ozawa, Tatsuya Kobayashi, Tomoyo Hasuda, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li, Haruhiko Fukaya, Reiko Yano, Yukio Hitotsuyanagi, Koichi Takeya,