Article ID Journal Published Year Pages File Type
5216765 Tetrahedron 2013 7 Pages PDF
Abstract

The sodium salts of the conjugated bases of uracils undergo highly chemoselective O4-monoalkylation when treated with various alkyl halides in dry DMF, while the use of methyl iodide results in N1+N3-dimethylation. Theoretical evaluations of the chemo- and regioselectivity along with X-ray crystallographic data are presented.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry