| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5216811 | Tetrahedron | 2014 | 8 Pages |
Abstract
Novel 2-iminiomethylvinamidinium trihalides were isolated as stable crystals and found to be useful triformylmethane synthons with non-deliquescent nature in air. They were easier to manufacture, handle, and store than the known 2-iminiomethylvinamidinium dichloride. By virtue of in situ aminal protection, a combination of the vinamidinium salt with a secondary amine achieved an efficient and scalable synthesis of 7-acylamino-3-formylquinoline, a versatile synthetic intermediate for potent anti-obesity drugs 7-acylamino-3-aminomethyl-8-methylquinolines.
Graphical abstractDownload high-res image (80KB)Download full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yasuhiro Sawai, Masahiro Mizuno, Tatsuya Ito, Mitsuhisa Yamano,