Article ID Journal Published Year Pages File Type
5216815 Tetrahedron 2014 6 Pages PDF
Abstract

A simple transition-metal-free protocol for the synthesis of indoles has been developed using aryne cycloaddition. The in situ-generated arynes couple with α-amino ketones through a one-step N-arylation-nucleophilic addition process under mild conditions and efficiently produce multisubstituted N-arylindoles.

Graphical abstractDownload high-res image (184KB)Download full-size imageSynthesis of multisubstituted N-arylindoles via cycloaddition of arynes.

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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