Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5216815 | Tetrahedron | 2014 | 6 Pages |
Abstract
A simple transition-metal-free protocol for the synthesis of indoles has been developed using aryne cycloaddition. The in situ-generated arynes couple with α-amino ketones through a one-step N-arylation-nucleophilic addition process under mild conditions and efficiently produce multisubstituted N-arylindoles.
Graphical abstractDownload high-res image (184KB)Download full-size imageSynthesis of multisubstituted N-arylindoles via cycloaddition of arynes.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lin He, Ji-Xin Pian, Jun-Feng Shi, Guang-Fen Du, Bin Dai,