| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5216876 | Tetrahedron | 2014 | 17 Pages |
Abstract
Model compounds of the left-half of renieramycins, which are anticancer marine natural products having an α-aminonitrile functionality, were prepared from phenylalanine derivatives. The key step of the transformation is the stereospecific construction of 1,3-cis stereochemistry via an exomethylene intermediate. The stereoselective α-aminonitrile formation under kinetically controlled conditions is also discussed. The initial cytotoxicity profiles are presented.
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