| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217031 | Tetrahedron | 2014 | 6 Pages |
Abstract
A concise and stereocontrolled synthesis of rosuvastatin calcium has been accomplished, with the key steps including a Keck enantioselective allylation of chloroacetaldehyde with allyltributylstannane to install 5R-stereocenter and a VO(acac)2-catalyzed syn-diastereoselective epoxidation of (S)-1-chloropent-4-en-2-ol to set the requisite 3R-chirality.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaofei Chen, Fangjun Xiong, Chen Zheng, Jie Li, Fener Chen,