Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217038 | Tetrahedron | 2014 | 6 Pages |
Abstract
A new general method for the synthesis of enols of cyclic 3-alkynyl-substituted 1,2-diketones is developed. Sonogashira cross-coupling of silyl enolates of cyclic 3-bromo-cyclopentane- and 3-bromo-cyclohexane-1,2-diones with variety of substituted acetylenes afforded enols of cyclic 3-alkynyl-1,2-diones with good yields (up to 93%) in a short reaction time. The starting 3-bromo-1,2-diones are easily obtainable by direct bromination of 1,2-diones with NBS.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anne Paju, Tõnis Kanger, Aleksander-Mati Müürisepp, Tiina Aid, Tõnis Pehk, Margus Lopp,