Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217047 | Tetrahedron | 2014 | 6 Pages |
Abstract
Bioactive indolo[3,2-j]phenanthridine alkaloids, calothrixin B and its N-oxide derivative calothrixin A have been synthesized via an oxidative free radical reaction. Calothrixin B is generated from the commercially available 2,4,5-trimethoxybenzaldehyde in only seven steps. The key step in this synthesis is the Mn(OAc)3 mediated oxidative free radical reaction of 9-(benzylamino)phenanthridine-7,10-dione with cyclohexenone to form 12-benzyl-12H-indolo[3,2-j]phenanthridine-7,13-dione.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Su Xu, Thao Nguyen, Irene Pomilio, Maria C. Vitale, Sadanandan E. Velu,