| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217076 | Tetrahedron | 2014 | 6 Pages |
Abstract
By employing an easily available [Ru(p-cymene)Cl2]2/Xantphos/t-BuOK catalyst system, the α-alkylation of ketones was demonstrated by using pyridyl methanol as the alkylating reagents. The synthetic protocol allows synthesizing a wide range of α-pyridyl methylated ketones in reasonable to excellent isolated yields with high atom-efficiency. The transformation is operationally simple, the substrate scope is wide, and the starting materials are readily-available. There is no need for addition of alkenes as the hydrogen receptors or the use of stoichiometric amount of base.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Feng-Xia Yan, Min Zhang, Xiao-Ting Wang, Feng Xie, Meng-Meng Chen, Huanfeng Jiang,