| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217077 | Tetrahedron | 2014 | 8 Pages |
Abstract
The synthesis of an advanced pyranonaphthalene spiroketal as an intermediate for the total synthesis of griseusin B is described. A one-pot Hauser-Kraus annulation-methylation via reaction of a highly-substituted enone with a cyanophthalide was employed to construct the naphthalene framework. Other key steps include Sharpless asymmetric dihydroxylation of a (Z)-alkene and an HF-pyridine mediated double TBS deprotection-spirocyclisation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Briar J. Naysmith, Daniel Furkert, Margaret A. Brimble,