| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5217148 | Tetrahedron | 2014 | 5 Pages |
Abstract
Enantioselective Michael additions catalyzed by hydrogen-bonding catalysts produce many important compounds. Solvent-free reaction conditions in a ball mill can provide an improved enantioselectivity over the reaction in solution, due to lack of disruptive solvation of reagents. A range of 15 structurally different hydrogen-bonding organocatalysts were tested in two Michael additions to β-nitrostyrene under solvent-free conditions and compared with corresponding experiments in solution. With several thiourea catalysts, these Michael additions proceeded with higher enantioselectivities under solvent-free conditions than in solution.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Martina Hestericová, Radovan Å ebesta,