Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217150 | Tetrahedron | 2014 | 5 Pages |
Abstract
β-Allyl-β-hydroxy dithioesters have been employed in the synthesis of hitherto unreported and synthetically demanding 2H-thiopyrans via regioselective intramolecular annulation strategy. Lewis acid BF3·Et2O efficiently mediates the regioselective dehydration followed by intramolecular thioannulation at room temperature. The attractive features of this protocol include mild conditions, high atom-economy and excellent yields with the elimination of water as the only by-product.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sushobhan Chowdhury, Tanmoy Chanda, Suvajit Koley, B. Janaki Ramulu, Keshav Raghuvanshi, Maya Shankar Singh,