Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5217153 | Tetrahedron | 2014 | 6 Pages |
Abstract
A novel Pd-C catalytic hydrodechlorination-hydrogenation was developed for a multi-step one-pot transformation of 4-acylpyridines. Under the selected conditions, 4-benzoylpyridines and 4-alkanoylpyridines were chemoselectively converted into the corresponding 4-benzylpiperidine hydrochlorides and α-alkyl-4-piperidinemethanol hydrochlorides, respectively. This catalytic method was performed simply by an addition of 1 equiv of ClCH2CHCl2 to the conventional hydrogenation system and directly gave the crystalline piperidine hydrochlorides in practical quantitative yields.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chuanjie Cheng, Bo Wang, Nan Liu, Wenwen Chen, Xinyan Wang, Yuefei Hu,